THE DUAL ROLE OF CXCL9/SPP1 POLARIZED TUMOR-ASSOCIATED MACROPHAGES IN MODULATING ANTI-TUMOR IMMUNITY IN HEPATOCELLULAR CARCINOMA

The dual role of CXCL9/SPP1 polarized tumor-associated macrophages in modulating anti-tumor immunity in hepatocellular carcinoma

IntroductionThe main challenge for cancer therapy lies in immuno-suppressive tumor micro-environment.Reprogramming tumor-associated macrophages (TAMs) into an anti-tumor phenotype is a promising strategy.MethodsA comprehensive analysis by combing multi-regional single-cell, bulk and spatial transcriptome profiling with radiomics characterization wa

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Displaced osteochondral fracture of the posterolateral tibial plateau associated with an acute anterior cruciate ligament injury

An osteochondral fracture of the posterolateral tibial plateau associated with an anterior cruciate ligament (ACL) injury in a 24-year-old boy is reported.Anterior BLACK PEPPER cruciate ligament rupture is accompanied by bone contusions resulting from the impact of the posterolateral tibial plateau bat on the anterior part of the lateral femoral co

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Monitoring, implementation and reporting of interventions in a selection of trials assessing exercise therapy for the management of shoulder subacromial pain: a cross-sectional investigation

Objectives To review the reporting of monitoring and implementation of interventions Colon Cleanse in a selection of trials that assessed the effectiveness of manual therapy and exercise in the management of shoulder subacromial pain.Design A review of trials assessing the effectiveness of manual therapy and exercise in the management of patients w

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